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KMID : 0390220040150020286
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2004 Volume.15 No. 2 p.286 ~ p.289
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A Case of Epstein-Barr Virus-associated Peripheral T-cell Lymphoma Involving Soft Palate and Left Palatine Tonsil in Renal Transplant Recipient
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Kim Sang-Ryul
Eom Jae-Wook
Choi Jung-Bae
Kim Chan-Hwan
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Abstract
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Posttransplant lymphoproliferative disorder (PTLD) is a heterogenous group of lymphoid proliferative disorders ranging from non-specific reactive hyperplasia to malignant lymphoma occurring in transplant patients. The origins of PTLD are mostly B lymphocytes and linked to Epstein-Barr virus (EBV) infection, but T lymphocyte PTLDs are uncommon and not associated with EBV infection. We report a case of EBV-associated peripheral T-cell lymphoma involving soft palate and left palatine tonsil occurring in a 35 year old female patient 14 years after renal allograft transplantation. Positivity for CD3 demonstrated in the tumor cells, while CD56 was not expressed. We detected positive reaction for EBV-encoded RNAs (EBERs) in the neoplastic cells by in situ hybridization. She is being treated by chemotherapy at present after surgical removal of lesion and reduction of immunosuppression.
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KEYWORD
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Posttransplant lymphoproliferative disorder (PTLD), Peripheral T-cell lymphoma, Epstein-Barr virus, Renal transplantation, Soft palate
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